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FITC標(biāo)記的中性*酯水解酶1抗體是我司為您提供的高品質(zhì)抗體，公司生產(chǎn)的每一個(gè)抗體都經(jīng)過(guò)嚴(yán)格檢測(cè)和穩(wěn)定性測(cè)試，保證了結(jié)果的準(zhǔn)確性、敏感性、特異性。公司產(chǎn)品質(zhì)量有保證，*且我司擁有完善的市場(chǎng)營(yíng)銷體系、現(xiàn)代化管理體系和專業(yè)化物流配送系統(tǒng)，zui大程度滿足國(guó)內(nèi)外生命科研人員的產(chǎn)品需求，公司現(xiàn)經(jīng)營(yíng)抗體、ELISA試劑盒、標(biāo)準(zhǔn)品、染色液、染色試劑盒、培養(yǎng)基等多種科研產(chǎn)品，歡迎前來(lái)選購(gòu)！
英文名稱 Anti-AADACL1/FITC
中文名稱 FITC標(biāo)記的中性*酯水解酶1抗體
別名 Arylacetamide deacetylase like 1; Arylacetamide deacetylase-like 1; Kiaa1363; NCEH; Nceh1; NCEH1_HUMAN; Neutral cholesterol ester hydrolase 1; Neutral cholesterol ester hydrolase.
說(shuō) 明書 100ug
研究領(lǐng)域腫瘤  免疫學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  腫瘤細(xì)胞生物標(biāo)志物
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat,
產(chǎn)品應(yīng)用 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分子量 46kDa
細(xì)胞定位細(xì)胞膜
性狀 Lyophilized or Liquid
濃度 2mg/1ml
免疫原 KLH conjugated synthetic peptide derived from human AADACL1
亞型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The assembly of very-low-density lipoproteins (VLDLs) in the secretory apparatus of the hepatocyte relies on the mobilization of triacylglycerol (TAG) from the cytosolic pool by lipolysis and re-esterification. However, some of the re-esterified TAG products are returned to the cytosolic pool in the liver, which protects vulnerable body tissues from excess lipotoxic non-esterified fatty acids in the plasma. Some of the lipases involved in this process include arylacetamide deacetylase (AADAC) and its related proteins AADACL1 and AADACL2. AADAC, a single pass type II membrane protein of the endoplasmic reticulum, is expressed in hepatocytes, intestinal mucosal cells, pancreas and adrenal gland. It plays an important role in the metabolic activation of arylamine substrates to ultimate carcinogens. AADACL1 hydrolyzes the metabolic intermediate 2-acetyl monoalkylglycerol, and its inactivation results in disruption of ether lipid metabolism in cancer cells and impaired cell migration and tumor growth.

Function:
Hydrolyzes 2-acetyl monoalkylglycerol ether, thepenultimate precursor of the pathway for de novo synthesis ofplaet-activating factor. May be responsible for cholesterolester hydrolysis in macrophages, thereby contributing to thedevelopment of atherosclerosis. Also involved in organdetoxification by hydrolyzing exogenous organophosphorus compounds.May contribute to cancer pathogenesis by promoting tumor cellmigration.

Subcellular Location:
Membrane; Single-pass type II membraneprotein (Probable). Microsome

Tissue Specificity:
Expressed in monocyte-derived macrophages. Up-regulated in invasive melanoma and breast carcinoma cell lines.

Post-translational modifications:
N-glycosylated.

Similarity:
Belongs to the 'GDXG' lipolytic enzyme family.

Database links: