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英文名稱 Anti-A2LD1/FITC
中文名稱 FITC標記的A2LD1蛋白抗體
別 名 A2ld1; GGACT_HUMAN; AIG2-like domain-containing protein 1; Gamma-glutamylaminecyclotransferase; GGACT.    
說 明 書 100ug  
研究領域 腫瘤  信號轉導  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse, Rat, Dog, Horse, Rabbit, 
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 17kDa
性 狀 Lyophilized or Liquid
濃 度 2mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human A2LD1 (1-50aa)
亞 型 IgG
純化方法 affinity purified by Protein A
儲 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
A2LD1 is a 153 amino acid protein belonging to the gamma-glutamylcyclotransferase family. A2LD1 contains two exons, with only the second exon coding, and spans 2.2 kb. Consisting of a monomer subunit, A2LD1 participates in acyltransferase and gamma-glutamylcyclotransferase activities. A2LD1 assists with the breakdown of proteins cross-linked by transglutaminases. A2LD1 also catalyzes the formation of 5-oxoproline from L-gamma-glutamyl-L-epsilon-lysine, but is inactive with L-gamma-glutamyl-alpha-amino acid substrates, such as L-gamma-glutamyl-L-alpha-cysteine and L-gamma-glutamyl-L-alpha-alanine. A2LD1 is encoded by a gene that maps to human chromosome 13q32.3.

Function:
Contributes to degradation of proteins cross-linked by transglutaminases. Degrades the cross-link between a lysine and a glutamic acid residue from two proteins that have been cross-linked by transglutaminases. Catalyzes the formation of 5-oxoproline from L-gamma-glutamyl-L-epsilon-lysine. Inactive with L-gamma-glutamyl-alpha-amino acid substrates such as L-gamma-glutamyl-L-alpha-cysteine and L-gamma-glutamyl-L-alpha-alanine.

Subunit:
Monomer.

Similarity:
Belongs to the gamma-glutamylcyclotransferase family.

Database links:

Entrez Gene: 87769 Human

Omim: 613378 Human

SwissProt: Q9BVM4 Human

Unigene: 350868 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.