產品名稱：Anti-Mouse/Rat Foxp3 PE
貨號：eBioscience 12-5773-82
規格：100ug
Anti-Mouse/Rat Foxp3 PE
Also known as: Forkhead Box P3, Scurfin, JM2, Treg
Clone: FJK-16s
Description: The FJK-16s antibody reacts with mouse, rat, dog, porcine, bovine and cat Foxp3 also known as FORKHEAD BOX P3, SCURFIN, and JM2; cross reactivity of this antibody to other proteins has not been determined. Foxp3, a 49-55 kDa protein, is a member of the forkhead/winged-helix family of transcriptional regulators, and was identified as the gene defective in ‘scurfy’ （sf） mice. Constitutive high expression of foxP3 mRNA has been shown in CD4+CD25+ regulatory T cells （Treg cells）, and ectopic expression of foxp3 in CD4+CD25- cells imparts a Treg phenotype in these cells.
Immunoblotting with FJK-16s antibody has mapped the epitope to amino acids 75-125 of the mouse Foxp3 protein. In the human, this region has been shown to be alternatively spliced at the mRNA level. Both the alternatively-spliced and non-spliced isoforms are present in the CD4+CD25+ subset of lymphocytes. Preliminary RT-PCR experiments have not revealed this alternatively-spliced isoform in mouse splenocytes, suggesting different gene regulation in the mouse and human.