產品名稱：Mouse TIM1-Fc Fusion Protein Carrier Free
貨號：eBioscience 16-5860-80 
規格：25 ug
Mouse TIM1-Fc Fusion Protein Carrier Free
Also known as: TIM-1, HAVCR1
Description: The Tim-1-Fc is a soluble fusion protein derived from expression of a fusion of cDNA encoding the entire extracellular domain of mouse Tim-1 to a cDNA encoding a human IgG1 Fc tail. TIM-1, a member of newly identified T cell immunoglobulin domain, mucin-like domain （TIM） gene family. TIM family of proteins are transmembrane proteins expressed by CD4 T cells. Recent studies demonstrate that the TIM family, particularly TIM-1, plays a critical role in immune responses that regulate the development of atopic diseases （e.g., asthma, allergic rhinitis, atopic dermatitis）. Human TIM-1 is a functional receptor for hepatitis A virus （HAV）. In humans, certain polymorphic variants of TIM-1 are strongly associated with protection against atopy, and this association occurs only in individuals who have had past infection with hepatitis A virus （HAV）. Activation of T cells through TIM-1 by HAV or by its natural ligand may affect T cell differentiation and the development of Th2-driven allergic inflammatory responses.