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Anti-CUG-BP1抗體,胞苷尿苷鳥苷結(jié)合蛋白1抗體

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產(chǎn)品簡介

“Anti-CUG-BP1抗體,胞苷尿苷鳥苷結(jié)合蛋白1抗體“抗體規(guī)格0.1ml、0.2ml、1ml，抗體產(chǎn)品有效期一年，質(zhì)保三個月，質(zhì)保期內(nèi)出現(xiàn)任何質(zhì)量問題或是出不了實驗結(jié)果均可免費退換：

詳細介紹

上海研盟生物科技有限公司Anti-CUG-BP1抗體,胞苷尿苷鳥苷結(jié)合蛋白1抗體*，主要應(yīng)用于WB、IHC、IF、ELISA、流式細胞術(shù)等實驗中。說明書隨貨發(fā)送，您也可以直接我司在線客服索取。客服

簡單介紹：

中文名稱：胞苷尿苷鳥苷結(jié)合蛋白1抗體

英文名稱：Anti-CUG-BP1

產(chǎn)品編號：byk-20525R

產(chǎn)品別名：Bruno like 2; bruno like protein 2; Bruno-like protein 2; BRUNOL 2; BRUNOL2; CELF 1; CELF-1; celf1; CELF1 CUGBP, Elav like family member 1; CELF1_HUMAN; CUG BP and ETR 3 like factor 1; CUG BP; CUG BP1; CUG RNA binding protein; CUG triplet repeat RNA binding protein 1; CUG triplet repeat RNA-binding protein 1; CUG-BP; CUG-BP- and ETR-3-like factor 1; CUG-BP1; CUGBP 1; CUGBP and ETR3 like factor 1; CUGBP; CUGBP Elav like family member 1; CUGBP Elav-like family member 1; CUGBP1; Cytidine uridine guanosine binding protein 1; Deadenylation factor CUG BP; Deadenylation factor CUG-BP; Deadenylation factor CUGBP; EDEN BP; EDEN BP homolog; EDEN-BP; EDEN-BP homolog; embryo deadenylation element binding protein; embryo deadenylation element binding protein homolog; Embryo deadenylation element-binding protein homolog; hNab 50; hNab50; NAB 50; NAB50; NAPOR; Nuclear polyadenylated RNA binding protein 50 kD; Nuclear polyadenylated RNA binding protein; RNA binding protein BRUNOL 2; RNA binding protein BRUNOL2; RNA-binding protein BRUNOL-2; 50 kDa Nuclear polyadenylated RNA binding protein; 50 kDa nuclear polyadenylated RNA-binding protein.

產(chǎn)品用途：科研實驗

產(chǎn)品價格：請報價

說明書：請?zhí)砑涌头苯铀魅?/p>

抗體來源：該指標有兩種產(chǎn)品，一種是兔來源抗體，一種是鼠來源抗體

克隆類型：兔來源為多克隆抗體，鼠來源單克隆抗體

交叉反應(yīng)：請索取說明書查看

性狀：Lyophilized or Liquid

濃度：1mg/1ml

亞型:IgG

純化方法: affinity purified by Protein A

儲存液: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol

保存條件: Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Anti-CUG-BP1抗體,胞苷尿苷鳥苷結(jié)合蛋白1抗體產(chǎn)品介紹：Myotonic dystrophy (DM) is an autosomal dominant neuromuscular disease that is associated with a (CTG)n repeat expansion in the 3’-untranslated region of the myotonin protein kinase gene (DMPK). CUG-BP1 and CUG-BP2 are proteins that bind specifically to (CUG)8 oligonucleotides in vitro. While CUG-BP1 has the major binding activity in normal cells, nuclear CUG-BP2 binding activity increases in DM cells. Both CUG-BP1 and CUG-BP2 are isoforms of a novel heterogeneous nuclear ribonucleoprotein (hnRNP), hNab50. CUG-BP1, an RNA CUG triplet repeat binding protein, regulates splicing and translation of various RNAs. Expansion of RNA CUG repeats in the DMPK in DM is associated with alterations in binding activity of CUG-BP1 as well as alterations in the translation of the C/EBPb transcription factor. CUG-BP1 is an important regulator of initiation from different AUG codons of C/EBPb mRNA. In normal cells, CUG-BP1 up-regulates the p21 protein during differentiation by inducing the translation of p21 via binding to a GC-rich sequence located within the 5’ region of p21 mRNA. In DM cells, failure to accumulate CUG-BP1 leads to a reduction of p21 and alterations in other proteins responsible for cell cycle withdrawl.

免疫組化的呈色深淺可反映抗原存在的數(shù)量，可作為定性、定位和定量的依據(jù)。

1.陽性細胞染色分布有三種類型：細胞漿、細胞核、細胞膜表面。大部分抗原見于細胞漿，可見于整個胞漿或部分胞漿
2.陽性細胞分布可分為灶型和彌漫性
3.由于細胞內(nèi)含抗原量不同，所以染色強度不一。如果細胞之間染色強度相同，常提示其反應(yīng)為非特異性
4.陽性細胞染色定位于單個細胞，且與陰性細胞相互交雜分布；而非特異性染色常不限于單個細胞，而是累及一片細胞。
5.切片邊緣、刀痕或褶皺區(qū)域，壞死或擠壓的細胞區(qū)，膠原結(jié)締組織等，常表現(xiàn)為相同的陽性染色強度，不能用于判斷陽性。

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