Anti-Guanylyl Cyclase alpha 2抗體,鳥苷酸環化酶α2/GCS-α-2抗體

英文介紹：Guanylate cyclases belong to the adenylyl cyclase class-4/guanylyl cyclase family. There are two forms of guanylate cyclase. The soluble form, known as GCS or sGC, act as receptors for nitric oxide (NO). The membrane-bound receptor form, known as GC, are peptide hormone receptors. GCS is a cGMP-synthesizing enzyme, which is the major receptor for the neurotransmitter nitric oxide. It plays a crucial role in smooth muscle contractility, plaet reactivity and neurotransmission. GCS is a heme-containing heterodimer, consisting of one alpha subunit and one beta subunit. The heme moeity mediates NO activation, and this heme group also binds carbon monoxide (CO), which weakly stimulates the enzyme. Both NO and CO stimulation are enhanced by the allosteric activator 3-(5'-hydroxymethyl-2'furyl)-benzyl-indazole, YC-1. YC-1 can also stimulate GCS in a NO-independent manner. Both alpha and beta subunits are required for cGMP generation, and at least two isoforms exist for each subunit. Heterodimers consisting of alpha-1/beta-1 and alpha-2/beta-1 have been identified, and both display similar enzymatic activity. The distribution of the beta-2 subunit seems to be much more restricted than the beta-1 subunit, with predominant expression in kidney and liver.
此產品本公司有標記的一抗出售，相關標記有：Alexa Fluor 350 標記、Alexa Fluor 488 標記、Alexa Fluor 555 標記、Alexa Fluor 647 標記、AP標記、APC標記、Biotin標記、Cy3標記、Cy5標記、Cy5.5標記、Cy7標記、FITC標記、Gold標記、HRP標記、PE標記、PE-Cy3標記、PE-CY5標記、PE-CY5.5標記、PE-CY7標記、RBITC標記
注意事項:This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

產品名稱:Anti-Guanylyl Cyclase alpha 2抗體,鳥苷酸環化酶α2/GCS-α-2抗體

產品編號：BYK-13545R
英文名稱：Anti-Guanylyl Cyclase alpha 2
中文名稱：鳥苷酸環化酶α2/GCS-α-2抗體
英文別名：GC SA2; GCS-alpha 2; GUC1A2; GUCSA2; GCYA2_HUMAN.
產品規格：0.1ml/0.2ml
此抗體本公司有單抗和多抗，可用于免疫組化（IHC），免疫印跡（WB），酶聯免疫(ELISA)，IF、IP、流式細胞術等實驗（可來電索取說明）
保存條件：Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Anti-Guanylyl Cyclase alpha 2抗體,鳥苷酸環化酶α2/GCS-α-2抗體抗孵育(Primary antibody incubation)：

一抗孵育(Primary antibody incubation)
參考一抗的說明書，按照適當比例用Western一抗稀釋液稀釋一抗。
用微型臺式真空泵吸盡封閉液，立即加入稀釋好的一抗，室溫或4℃在側擺搖床上緩慢搖動孵育一小時。如果一抗孵育一小時效果不佳，可以在4℃緩慢搖動孵育過夜。回收一抗。加入Western洗滌液，在側擺搖床上緩慢搖動洗滌5-10分鐘。吸盡洗滌液后，再加入洗滌液，洗滌5-10分鐘。共洗滌3次。如果結果背景較高可以適當延長洗滌時間并增加洗滌次數。

二抗孵育(Secondary antibody inucubation)
參考二抗的說明書，按照適當比例用Western二抗稀釋液稀釋辣根過氧化物酶(HRP)標記的二抗。
用微型臺式真空泵吸盡洗滌液，立即加入稀釋好的二抗，室溫或4℃在側擺搖床上緩慢搖動孵育一小時。回收二抗，加入Western洗滌液，在側擺搖床上緩慢搖動洗滌5-10分鐘。吸盡洗滌液后，再加入洗滌液，洗滌5-10分鐘。共洗滌3次。如果結果背景較高可以適當延長洗滌時間并增加洗滌次數。

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